goal is to target adequate area under the concentration–time curve (AUC) with an undetectable trough (predose) plasma concentration.critically ill with severe sepsis or septic shock.patients with altered gentamicin pharmacokinetics:.

empirical therapy (up to 48 hours of therapy) and renal function is changing rapidly or in patients with altered pharmacokinetics.

List of drugs that typically undergo therapeutic drug monitoring, with their therapeutic range: Drug to assist diagnosis – adverse drug effects may mimic disease state.to assess for drug toxicity or suspected overdose.if there is a change in a patient’s physiology (eg.when starting or stopping a potentially interacting drug.Indications for therapeutic drug monitoring include: a suitable and accessible laboratory assay.seizures, transplant rejection) if there is therapeutic failure desired therapeutic effect difficult to monitor.defined therapeutic (target) concentration range.concentration related therapeutic and adverse effects.marked pharmacokinetic variability (inter- or intra-individual).aminoglycosides)ĬHARACTERISTICS OF DRUGS SUITABLE FOR THERAPEUTIC DRUG MONITORING AND INDICATIONSĭrugs suitable for therapeutic drug monitoring have these characteristics: there is a narrow therapeutic window with a risk of serious toxicity (e.g.the drug effect is the absence of something (e.g.heart rate with beta-blockade), however, TDM is particularly useful where: drug concentration at the receptor and the response (pharmacodynamic variability)Ĭlinical efficacy is generally preferred for monitoring drug response (e.g.dose and plasma concentration (pharmacokinetic variability).This helps address the two major sources of variability in drug responses between individuals, the relationships between: Therapeutic drug monitoring (TDM) is the individualization of drug dosage by maintaining plasma or blood drug concentrations within a target range (the ‘therapeutic window’)

Therapeutic index calculator